Serena Williams of the United States reacts while being interviewed after her defeat in the Women's Singles finals match to Naomi Osaka of Japan on Day Thirteen of the 2018 US Open at the USTA Billie Jean King National Tennis Center on September 8, 2018 in the Flushing neighborhood of the Queens borough of New York City.
Williams made a solid start to Sunday's contest in California as she raced into a 3-0 lead, dominating from the baseline with a string of powerful forehands.
"Before the match, I did not feel great, and then it just got worse with every second; extreme dizziness and extreme fatigue", Williams said in comments released via tournament organizers.
"I felt that maybe she wasn't feeling well", she said.
Williams, 37, had shown signs of fatigue during the first set and after it was completed she called for a trainer and following a lengthy conversation returned to the court. "It's extra motivation for me to play just a little bit better out there".
Serena Williams bowed out of the Indian Wells Open due to illness, while Simona Halep and Elina Svitolina enjoyed strong wins.
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While the pair have maintained they share a good relationship but Eden Hazard did not have the best time of his career when he was playing under Jose a couple of seasons ago.
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Earlier in the day, the event took another loss as former world number one Jason Day withdrew because of a back injury. The Mount Juliet golfer eagled the 18th to race to the turn in four-under 32 and move into the top-10 on five-under.
It's the second time in four years that Williams has withdrawn from the tournament.
She is now ranked 10th in the world. The former World No.1 extended her lead even further by breaking McHale at love for a 5-1 lead, punctuating that game with a bruising forehand service return for a clean victor.
World No.97 Barthel, a former Top 25 player, notched her second Top 20 win in a row with a third-round upset of her countrywoman Julia Goerges, the No.15 seed, 7-5, 1-6, 6-4.
Sixth-seeded Elina Svitolina also advanced, holding of Australian Daria Gavrilova 7-5, 6-4.
She had defeated Victoria Azarenka 7-5 6-3 in her first match on Friday.