"What are you supposed to feel about your mother?" she said, according to TMZ.
Vernita did not raise Oprah for the first part of her life, as the presenter went to live with her maternal grandmother in rural MS after Vernita moved to Milwaukee to work as a housemaid.
Oprah had two half-siblings on her mother's side - Jeffrey, who died of AIDS in 1989, and Patricia, who passed away in 2003.
Oprah has yet to issue a statement to address her mother's passing.
Lee later appeared on Winfrey's talk show in 1990, where her personal stylist gave her a makeover. Oprah's spokesperson says that a private funeral has already taken place.
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Lee is also survived by another daughter, Patricia Amanda, and four grandchildren.
Lee worked as a housemaid, moving the family to Milwaukee when Oprah was six.
Oprah is the oldest of Vernita's children.
The death was first revealed by Oprah's niece Alisha Hayes on Facebook, and confirmed by representatives for the star.
There are reports Vernita retired from a hospital dietitian job sometime after she reconnected with O, moved into a luxury condo in Milwaukee and got a stipend from her famous daughter of $5k a month.
Oprah reportedly supported her mother financially. Lee, but there's not enough room on our docket for your daughter. Lee gave birth to Oprah's younger half-sister, who died in 2003. "I don't really even know my mother", Oprah said of the childhood move, Newsweek reported.