ISIS claimed responsibility for that attack.
Unknown gunmen on Friday attacked a bus carrying Coptic Christians to a desert monastery in southern Egypt, killing seven people, police said.
Seventy-four people were killed in the attacks in 2016 and 2017 targeting Coptic Christians in Cairo, Alexandria and the Nile Delta city of Tanta.
President Abdel Fattah Al Sisi issued official statements in which he mourned the victims and re-affirmed his effors to combat terrorism on his Twitter and Facebook accounts.
"There is a mix of sadness and pain; sadness as these painful events are being repeated and pain because Copts are part of this homeland and part of its fabric", Bishop Macarius, head of the Coptic diocese in Minya, told mourners at the Prince Tadros Church in Minya, tears streaming down his face.
Locals said the minibuses were part of a convoy of three carrying pilgrims from the remote desert monastery.
Last month, the Egyptian military sentenced 17 people to death for suicide bombings at churches claimed by IS and 29 others were given long jail sentences.
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Copts, a Christian minority that make up 10 per cent of Egypt's 96 million people, have in recent years been repeatedly targeted by the Islamic State jihadist group. "This attack will not weaken the will of our nation in continuing its battle to prevail and build", the president, who called Pope Tawadros II to express his condolences, added.
On Saturday, el-Sissi is to open the World Youth Forum in the Sharm El Sheikh resort in Sinai, which has also seen deadly militant attacks.
A total of 19 were wounded in the attack, according to the Coptic Orthodox Church.
Embarrassingly, Friday's attack is the second to target pilgrims heading to the St. Samuel the Confessor monastery in as many years, indicating that security measures put in place since then are either inadequate or have become lax.
In December past year ISIS claimed responsibility for a gun attack on a Coptic Christian bookshop and church in Cairo that killed nine people.
The attack previous year was the latest in a deadly series that targeted churches in Cairo, the Mediterranean city of Alexandria and Tanta in the Nile Delta north of the capital.
In December 2017 an IS militant killed nine people in an attack on a church in a south Cairo suburb.