Keita, holding his thigh, was substituted in the first half of the fixture in Rwanda on Tuesday.
However, there has been no confirmation for Liverpool about Mane's injury.
Mane returned to Liverpool for the procedure and will be monitored by the club before their trip to Huddersfield in the Premier League on Saturday.
Mane played the full 90 minutes in Liverpool's goalless draw with Manchester City before the worldwide break but picked up an injury while training with Senegal in the lead-up to their clash with Sudan.
With just a few days remaining for all five players to recover from injury, Liverpool might have to go into Saturday's game without all of them which would leave Klopp needing to field a vastly different side to the one which took on City two weeks ago.
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The Boston Red Sox say ace left-hander Chris Sale has a stomach illness and will spend the night in the hospital. So if the Astros go up 2-0, with the next three games in Houston , things start looking pretty dire for Boston.
Senegal striker Sadio Mane sustained a suspected broken thumb in training before the Africa Cup of Nations qualifier with Sudan.
Reds forward Mohamed Salah, midfielder Naby Keita and defender Virgil van Dijk also suffered injuries while on worldwide duty this week.
Meanwhile, Liverpool are now occupying third position on the Premier League standings with 20 points after eight games played so far this season.
Van Dijk, 27, broke two of his ribs against former club Southampton on September 22nd but has carried on playing and joined up with the Netherlands for the worldwide break.