Dominic Grieve, the former Attorney General, took up the Lords' meaningful vote clause and ran with it in the Commons.
Peers defeated the Government on 15 issues, introducing amendments on issues ranging from future United Kingdom membership of the customs union and European Economic Area (EEA) to ministers' use of "Henry VIII" powers to force through changes without parliamentary scrutiny and the questions of whether MPs should get a "meaningful vote" on the final Brexit deal.
On Tuesday, the Government avoided a potentially devastating defeat over the EU Withdrawal Bill, which would have otherwise seen unprecedented powers handed to MPs to reject the agreement reached with Brussels and to dictate the Prime Minister's next steps.
"I absolutely trust what the Prime Minister says to us". The government earlier had said it would not support that amendment.
"We have not, and will not, agree to the House of Commons binding the Government's hands in the negotiations".
Brexit minister David Davis warned lawmakers the government would never allow them to reverse Brexit.
Other flashpoints in the parliamentary votes include proposals to keep Britain tightly aligned with the EU's economy.
In a day of drama, May's position seemed suddenly weaker when junior justice minister Phillip Lee, who has always been critical of the government's Brexit strategy, resigned and said he would vote against the government.
The vote was one of the most important in two days of votes that began Tuesday on the government's EU Withdrawal Bill.
Sir Keir said a Government compromise on a meaningful vote for Parliament at the end of the Brexit process would instead turn it into a "meaningless vote" if backed by MPs.
Apple Aims to Solve Problems Locating 911 Calls for Help
Individual call centers will each have to embrace the technology required to communicate with the RapidSOS clearinghouse. Apple will also use technology from emergency technology company RapidSOS to share HELO location data with 911 centers.
Another record! Second World Cup's quickest red card
Keisuke Honda is the first player from an Asian nation to provide an assist in three different World Cup tournaments since 1966. The 2-1 victory over Colombia on Tuesday (Wednesday NZ Time ) was another surprising result in an unpredictable tournament.
Sri Lanka cricket captain pleads not guilty to ball tampering
The charges had been laid by on-field umpires Aleem Dar and Ian Gould, and third umpire Richard Kettleborough on Saturday. At the conclusion of the day's play, Sri Lanka Cricket released a statement.
Tuesday's Commons debate marked the start of the government's attempts to undo most of the changes to its EU Withdrawal Bill that were put forward by the House of Lords.
Remainer Stephen Hammond said a group of potential rebels - believed to number 15 to 20 - received assurances from the PM moments before the key vote.
This amendment gives Parliament control in the final stages of Brexit, preventing the government from signing a deal with the European Union that hasn't been approved by lawmakers.
The only GP in a minister post has announced his resignation over current Brexit policy, calling it "detrimental to the people we are elected to serve".
Mr Grieve said no government would survive if it tried to dispense with Parliament's input.
Brexit Secretary David Davis, who reportedly has clashed with May, has warned Conservative Party rebels that proposals to give Parliament the power to direct negotiations with the European Union are simply a tactic to overturn the results of the 2016 referendum that mandated Britain's departure from the bloc.
But it was a vote in parliament on Tuesday that left her seemingly at the mercy of two groups in the Conservative Party - those who want to maintain the closest possible ties with the European Union, and others pressing for a clean break.
But Tory MP Andrew Bridgen, a leading Brexit backer, said the concessions could "come back to haunt" the government if they amounted to a veto over the terms of the UK's departure.
He also insisted he wanted to "speak up for his constituents" - even though Eurosceptics pointed out his Bracknell seat voted 53 per cent to Leave in the referendum.
Ukip leader Gerard Batten said: "The only "meaningful vote" was the verdict of the people in referendum of June 23 2016".