"We've seen this many, many times".
Dimmit County Sheriff Marion Boy told WOAI the crash happened off Highway 85 in Big Wells at about noon.
"It's just extremely busy, we need the assets down here, we have a problem", Boyd said. One person died at a San Antonio hospital.
He said there were 14 people in the vehicle.
It appears the SUV was being pursued by both Border Patrol agents and sheriff's deputies.
Border patrol agents use all-terrain vehicles (ATV) to search for illegal immigrants along the US.
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He added: 'This is a ideal example of why our borders need to be secure'.
In a statement, the Border Patrol said the chase began after an agent spotted "three vehicles traveling in tandem pass his location on a rural highway" and the agent suspected that "a smuggling event was taking place".
The driver and passenger are USA citizens and are likely to face state and federal charges, Boyd said.
Authorities are investigating the scene where a auto full of undocumented immigrants being chased by Border Patrol agents crashed.
The driver is now in custody with Homeland Security Investigations, a division of the Department of Homeland Security, according to the Texas Department of Public Safety. Six patients were taken to San Antonio Military Medical Center in San Antonio, Lt. Edwin Roberts said. The vehicle was traveling around 100 miles per hour, the sheriff said.
"Our deepest sympathies go out to the families of those who died in the crash", The Border Patrol said in the statement.