The Saints were due to stay at the city's Marriott Hotel ahead of their game against Swansea at the Liberty Stadium on Tuesday evening, but were told at short notice that the venue was unavailable to them because of a "virus outbreak".
It means only a highly unlikely goal-difference swing on the final day of the season will send them down.
Huddersfield needed a point to move out of reach of Swansea City - and achieved that despite Marcos Alonso canceling out Laurent Depoitre's opener.
This, as a result, consolidated David Wagner's side's stay in the league for another season with a point accumulation of 37and a game to spare.
Current caretaker manager, Darren Moore's rescue act of 11 points from five games, including a 1-0 win at Old Trafford, was, sadly, too late to stop West Brom from ending their eight-year stay in the EPL, joining Stoke City who were relegated last weekend.
The ex-Barcelona star, who delivered a League Cup in 2013, left the Liberty Stadium in February 2014 after getting the sack for a run of six defeats in eight league matches. This situation draws parallels with a club in Germany two seasons ago when Hoffenheim were in a similarly desperate position to the one West Brom found themselves in, albeit earlier in the season.
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The Italian, who won the league last season in his first campaign in charge at Stamford Bridge, is under contract until June 2019. Conte made six changes, but insisted his side should still have prevailed. "It's stupid if we think rotation was a problem".
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Swansea City are 17th on log sheet with 33 points minus 27 goals, while Southampton are 16th with 36 points minus 18 goals.
Yet, his mission was accomplished after substitute Manolo Gabbiadini's second-half victor moved Southampton three points clear of the drop zone for their second league win in three games.
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Swansea's best chance of survival now seems to rest on overcoming Stoke and seeing Huddersfield lose their final two games, at Chelsea on Wednesday and at home to Arsenal on Sunday.
Whilst the reverse fixture was a respectable 2-1 to the Manchester side, they have been totally ruthless all season and with no other competitions to prepare for, they could easily name a full-strength side and go out and romp the Saints this Sunday.
It's all shaping up for a dramatic final day.