In a phone call, Russian President Vladimir Putin and Israeli Prime Minister Benjamin Netanyahu warned each other about the repercussions of actions related to Iran's presence in Syria.
Syria's T-4 military airbase, in the central province of Homs, was hit by an air strike on Monday.
Netanyahu told Putin that Israel would press a campaign to prevent Iran's military entrenchment in Syria, his office said.
Russian President Vladimir Putin, left, shakes hands with Israeli Prime Minister Benjamin Netanyahu during an event marking International Holocaust Victims Remembrance Day at the Jewish Museum and Tolerance Center in Moscow, January 29, 2018.
Netanyahu, for his part, said then that Israel would continue to counter Iran's efforts to build up its military presence in the war-torn country.
In a telephone call, Putin urged Netanyahu "to abstain from any action that could further destabilise the situation in the country, which would represent a threat to its security", the Kremlin said in a statement.
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Iran is a key ally of the Syrian government, alongside Russian Federation.
The Israeli strikes reportedly targeted an "advanced system" that could undermine Israel's air superiority in Lebanese and Syrian airspace, according to Hadashot TV.
While Russia, Iran and Syria have accused Israel of carrying out the pre-dawn attack, Tel Aviv has refused to comment.
Israel has said repeatedly that it can not tolerate an extended Iranian presence in Syria and reportedly has launched air raids to keep Iran from delivering weapons to Hezbollah.
However, in the wake of last week's alleged chemical weapons attack by the Assad regime, Trump appears ready to intensify US involvement in the region.