"Newcastle United's players and, of course, their staff gave what they have and what they don't have and I think that's a handsome thing in football", said Mourinho, who has never presided over a Premier League -victory in seven attempts at St James' Park and saw his side undone by Matt Ritchie's -second half victor.
The France worldwide has scored three times and set up a further nine in 16 Premier League appearances this season as United look to challenge Manchester City to the title, but faced criticism for his performance in a recent 2-0 defeat to Tottenham Hotspur.
Worse was to follow for Mourinho, with Liverpool winning 2-0 at Southampton to trim the gap to second-placed United to two points with 11 games left.
Newcastle United fans have taken to social media to praise the performance of goalkeeper Martin Dubravka as he made his kept a clean sheet on his debut for the club against Manchester United on Sunday.
Newcastle's claim for a deserved penalty in the first half was not given by the referee Craig Pawson.
Ritchie's run was completely untracked by United's sloppy defence and the Newcastle winger fired low past David De Gea.
Coverage of today's Premier League game between Newcastle Utd and Manchester Utd will be shown live on Sky Sports Main Event (Sky channel 401, Sky HD 435, Virgin channel 511) and Sky Sports Premier League (Sky channel 402, Sky HD 436, Virgin channel 512).
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Adding to Mourinho's frustration, the goal stemmed from a free-kick awarded for a needless dive by United defender Chris Smalling. "That's the feeling. Anthony [Martial] in the first and in the second half Alexis [Sanchez] with an open goal".
The midfielder has been linked with a move to the Premier League for a long time with Zinedine Zidane regularly preferring different options in his starting line-up. The visitors haven't lost away to Newcastle since 2012.
"When he's asked to do a job centrally, he's forever straying towards the touchline trying to get on the ball".
Smalling inexplicably gave a free-kick away in his own half because of a dive over Shelvey - and was booked for his pathetic effort.
Elsewhere at the John Smith's Stadium, Huddersfield climbed out of the relegation zone after a 4-1 win against Bournemouth.
The Red Devils came close to an equaliser on 76 minutes, with Martial having two shots blocked on the line as Newcastle struggled to clear a corner.
It proved to be a huge miss as Newcastle soon took the lead.