New York City fire department tweeted that over 200 fire fighters continued to fight the fire at 1547 Commonwealth Ave' in Bronx.
It was also reported that at least 150 firefighters were battling the fire.
At least 22 people were injured in a seven-alarm fire in the Bronx Tuesday, according to fire officials.
The cause of the fire is not immediately known.
The incident took place on Thursday night and has been termed as the deadliest fire to hit NY in more than 25 years.
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One resident escaped the burning building with his three young children.
The flames broke out after 5am (9pm AEDT) in the Van Nest area of the Bronx in a building that houses a furniture store on the first floor and apartments on the upper floors.
This is a second incident in less than a week. after the incident where a 3-year-old playing with a stove had accidentally put the house on fire which claimed 12 lives including four children.
NY mayor Bill de Blasio described the incident as "the worst fire tragedy we have seen in this city in a quarter century".