Forecasters warn the extreme weather is likely to cause travel chaos and potential power outages as the area of intense low pressure moves in from the Atlantic.
Dave Reynolds, a forecaster for The Weather Company, said: "This storm is going to be large enough to affect the whole of the UK".
Experts say dramatic weather conditions created by the phenomenon, caused when central pressure in an area of low pressure falls rapidly, will see 60mph winds hit parts of southern Britain this morning.
Severe weather warnings have been issued with flash floods, strong winds and huge waves expected to lash Wales and the South of England on Saturday.
While Co. Tipperary is not included in the list of counties with high-wind warnings, neighbouring counties Clare, Cork, and Waterford are.
"Gusts exceeding 50mph are expected widely within the warning area, with gusts of around 70mph along exposed coastal areas".
Strong winds had already hit southern and south-western parts of Ireland by early Saturday morning.
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Alison Baptiste, national flood duty manager for the Environment Agency, warned the public against social media stunts during the bad weather.
"EA teams are on the ground checking defences and taking precautionary measures such as closing tidal gates". The gusts could bring more power cuts after Ophelia left 50,000 people in the United Kingdom and 170,000 in Ireland without power, and could also cause flooding and large waves.
'Speed restrictions may be imposed in the worst affected areas for safety reasons, which may delay your journey'.
Drivers were also urged to take extra care on the roads because surface spray, reduced visibility and potential flooding remained high risks.
The Energy Networks Association, representing the UK's energy infrastructure, also reminded residents to call the free 105 advice telephone number in case of damage to local networks and power supplies.
Despite Storm Aileen hitting the United Kingdom last month, and Ophelia earlier this week, Brian is the second, rather than third named storm of the year, as Ophelia was named as a hurricane.