Reed birdied the 15th and world number two Spieth followed up with a birdie on the par-three 16th to make the match flat.
However, the first point of the day for the Americans came courtesy of Cup rookies Charley Hoffman and Kevin Chappell, who responded to Stricker's call up by combining brilliantly to dispose of Anirban Lahiri and Charl Schwartzel 6&5.
Spieth saved par from 33 feet on the par-4 11th hole to set up another American victory for him and Patrick Reed, winning 5-and-4 against Emiliano Grillo and Si Woo Kim, while Johnson and Matt Kuchar fought hard from a shaky start to record a one-up win over Adam Scott and Jhonattan Vegas.
World Number 1 Johnson caught fire on the back 9 and wrapped up the match for the US on the 16th winning 3 & 2.
Mickelson again came up trumps on the Presidents Cup stage, all square before a clutch birdie on the 18th from the veteran stole the match from the Aussie's 1up.
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"I think we saw the strength of the USA team come out today but in all fairness to my guys, I don't think they played as well as they were capable of", said worldwide captain Nick Price, who was refusing to wave the white flag.
He also saw his team play its worst golf on the back nine at Liberty National.
Price was not about to give up, hopeful of gaining some momentum in the morning and riding it into the afternoon ahead of the 12 singles matches on the final day.
It looked a little awkward, though Mickelson did slightly better than when he cropped most of his face out of a selfie he took during the opening ceremony with the last three USA presidents. "This reminds me a lot of the 2008 Ryder Cup team when we finally were able to win at Valhalla", Stricker said.
Given their friendship, their homes in proximity, their frequency of practice rounds, Thomas and Fowler give the US a formidable team not just for this week, but for future Cups to come. He and Reed stole a half-point against Matsuyama and Hadwin in Friday's four-ball session, so the Americans are likely to keep their hot streak rolling into the weekend.
Their story encapsulated the troubles for the Internationals; starting with three consecutive birdies they had control of the match, then gradually surrendered it. "I know his game very well and he knows mine very well, and it's fun to put the two together and go out and win our first team point".
"They made a lot of putts on the back nine to halve holes", Thomas said. Grace and Oosthuizen got it back to all square with a birdie at the 11th, and that's where the match would end at the 18th, with a half point going to each team.