Stanley shot a six-under-par 64 to take the first-round lead at East Lake Golf Club and put himself in contention to win the PGA Tour's four tournament playoff series.
Patrick Reed, Justin Rose, Gary Woodland and Jon Rahm finished Round 2 one shot back at 6 under.
Of course, with two rounds to play there is far too many permetations and with Casey happy at least the likes of FedEx Cup front-runner, Jordan Spieth back at three-under with scores of 67 and 70.
Kyle Stanley of the United States plays his shot from the eighth tee during the first round of the Tour Championship at East Lake Golf ClubJordan Spieth of the United States plays a shot from a bunker on the ninth hole in Atlanta, Georgia. "But I felt like maybe that would be key, just hitting a lot of fairways and giving myself chances on second shots".
JUSTIN THOMAS, on his 235-yard approach shot to within five feet of the final hole, where his eagle gave him a four-under 66 and 133 total. He finally finished with a double-bogey six.
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Dustin Johnson and Jordan Spieth are four shots back.
Casey became a father for the second time last week, but his bid for a £8.5million jackpot in the FedEx Cup play-offs meant he could he had to miss the birth, and he has still not seen his baby daughter. Since then he has claimed 15 top five finishes - three more than any other "win-less" player has managed in the same period.
"It's pretty good. It would be nicer if I was at home with my daughter and my son and my wife, but I love doing what I do", Casey said.
"I've had a very good one and I would like to turn it into a great one and the way to do it would be with victory this week".
"The World Tour - it's going to happen one day and I think it has to", said the Northern Irishman.