The New York Times first reported his passing.
Blazer swept up evidence that formed the foundations of a Department of Justice case against world soccer executives who embezzled cash from commercial contracts and sought payments in return for backing countries as World Cup hosts.
Blazer was also a member of FIFA's Executive Committee from 1996 to 2013, giving him the power to control the world's game.
Mr Blazer served as a government informant in helping uncover the corruption within the soccer governing body.
Banned US football official was at the centre of a global corruption scandal that toppled ex-FIFA boss Sepp Blatter. When the Trinidadian won, he made Blazer the general secretary.
In 2015, the same year that his testimony and admittance of accepting bribes with other FIFA Executive Committee members became public knowledge after a sealed transcript was formally unsealed, he was banned by FIFA from all football activities for life.
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By December 2011, US federal law enforcement officials approached Blazer on the street outside Trump Tower and presented him with their evidence of his tax evasion and wire fraud, including Caribbean bank accounts and other malfeasance.
A statement from Blazer's two lawyers did not provide details or the circumstances of his death. Partly as a result of that, to date more than 40 individuals and entities have been charged, most notably Jack Warner, the notorious former CONCACAF president with whom Blazer worked for years and who has been cited as allegedly one of the biggest culprits in the entire corruption scandal.
"At one moment, he looked at me with a very serious gaze and said, without cracking a smile, "You know, you look like Karl Marx!" The only acknowledgement of Blazer's death by U.S. Soccer was a comment in a news conference by national team coach Bruce Arena.
He said at the time that he had rectal cancer, diabetes and coronary artery disease. He did a lot for the sport. Warner and Bin Hammam were also banned by Federation Internationale de Football Association for life.
The statement continued: "Chuck felt profound sorrow and regret for his action". He reportedly had one apartment in Trump Tower for himself and another just for his cats.
It said he "accepted responsibility for his own conduct by pleading guilty and owning up to his mistakes".