They join hosts Russian Federation and five-time World Cup winners Brazil in securing their spot for next summer.
The top two teams in each group will qualify automatically for Russian Federation 2018, with the third-placed teams set to meet each other for the right to face the fourth-placed team in the CONCACAF final qualifying group.
Goals from Sardar Azmoun and Mehdi Taremi earned Islamic Republic of Iran their place at the finals of the FIFA World Cup in Russian Federation next year as Carlos Queiroz's team downed Uzbekistan 2-0 at the Azadi Stadium on Monday.
This is the fifth qualification to the global finals for Iran, having previously appeared at football's showpiece event in 1978, 1998, 2006 and 2014.
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It is the first time Iran has qualified for consecutive World Cups, and will be its fifth appearance at soccer's marquee tournament.
Team Melli's victory on Monday not only guaranteed their safe passage to the 2018 World Cup, but ensured they did so in style with two Group Stage matches to spare. The team is unbeaten from eight games and eight points clear of third-placed Uzbekistan with two qualifiers remaining, so can not be denied a top-two finish and an automatic spot in Russian Federation next year.
Sardar Azmoun scored in the 23rd minute and Mehdi Taremi added in the 88th at Azadi Stadium in Tehran.
It was Iran's sixth win from eight matches in Group A which took the table-toppers to 20 points, while South Korea are second on 13 ahead of their match against Qatar today.