Heads Together released a short film showing William discussing mental health issues with the US popstar Lady Gaga, who has gone public with her own struggles with post-traumatic stress disorder (PTSD) after she was raped aged 19.
"There's a lot of shame attached to mental illness, you feel like something's wrong with you".
As part of the Heads Together #oktosay series, William has filmed a FaceTime call with Gaga to discuss mental health openly in an effort to reduce stigma.
Prince William added: It's time that everyone speaks up and that everyone feels very normal about mental health, it's the same as physical health. She explained a few of her conditions, including dissociation and her inability to express her feelings when a fight or flight response takes over her body.
"For me waking up every day and feeling sad and going on stage is something that is very hard to describe".
"Harry, Catherine and I really felt this was such an important area that throughout all our charitable work, whether it was the veterans, homelessness, addiction, most of it seemed to stem back to mental health issues", he said of his work with his brother, Prince Harry, and wife, Kate Middleton. "And I wanted to ask you very much how you found speaking out and how it made you feel".
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Suicide is the biggest killer of men under 45 in Britain, and William said seeing the impact of suicide through his work as a an air ambulance helicopter pilot had been a "tipping point" in his decision to campaign on mental health issues.
"Even though it was hard, it was the best thing that could come out of my mental illness was to share it with other people and let our generation as well as other generations know that if you are feeling not well in your mind, you are not alone".
"Sometimes, emotions have to be put to one side to get the job done, but if you have been through an especially traumatic or stressful situation it is essential to talk it through after the event", Prince William said.
Prince William believes it is time to move on from the British "stiff upper lip" culture of burying one's emotions at the expense of their own well-being.
The comments by Queen Elizabeth's grandson came a day after his younger brother Prince Harry spoke about his struggles coping with the loss of his mother Diana in an unusually revealing interview.
The fifth in line admitted he sought counseling to help him deal with his own grief.